Phorbol Ester Enhances KAI1 Transcription by Recruiting Tip60/Pontin Complexes
نویسندگان
چکیده
منابع مشابه
Phorbol ester enhances KAI1 transcription by recruiting Tip60/Pontin complexes.
Down-regulation of the KAI1 (CD82) metastasis suppressor is common in advanced human cancer, but underlying mechanism(s) regulating KAI1 expression are only now being elucidated. Recent data provide evidence that low levels of KAI1 mRNA in LNCaP cells are caused by binding of beta-catenin/Reptin complexes to a specific motif in the proximal promoter, which prevents binding of Tip60/Pontin activ...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2008
ISSN: 1476-5586
DOI: 10.1593/neo.08850